Article
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
PloS one - 20 Nov 2009
Willuweit Antje, Velden Joachim, Godemann Robert, Manook Andre, Jetzek Fritz, Tintrup Hartmut, Kauselmann Gunther, Zevnik Branko, Henriksen Gjermund, Drzezga Alexander, Pohlner Johannes, Schoor Michael, Kemp John A, von der Kammer Heinz
Abstract excerpt
BACKGROUND: Transgenic mice expressing mutated amyloid precursor protein (APP) and presenilin (PS)-1 or -2 have been successfully used to model cerebral beta-amyloidosis, one of the characteristic hallmarks of Alzheimer's disease (AD) pathology. However, the use of many transgenic lines is limited by premature death, low breeding efficiencies and late onset and high inter-animal variability of the pathology,...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Amyloidosis
- Animals
- Disease Models, Animal
- Female
- Homozygote
- Humans
- Male
- Mice