Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models

7 Feb 2025

Abstract excerpt

Abstract APP knock-in (KI) mice serve as an exciting new model system to understand amyloid beta (Aβ) pathology, overcoming many of the limitations of previous overexpression-based model systems. The APPSAA mouse model (containing the humanized APP with three familial Alzheimer’s disease mutations) and the APPWT control (containing wildtype humanized APP) are the first commercially available APP KI mice within...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Regulation of Appetite and Obesity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39920176
DOI: 10.1038/s41598-025-89051-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse modelsPMID 39920176Read ↗

APP-KI mice do not display the hallmark age-dependent cognitive decline of amyloid diseasesSemantic proximity Read ↗

Cognitive deficits in single App knock-in mouse modelsSemantic proximity Read ↗

Histological and Behavioral Phenotypes of a Novel Mutated APP Knock-In Mouse.Semantic proximity Read ↗

New mouse model of Alzheimer's.Semantic proximity Read ↗

Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E genotype-dependent accumulation of amyloid β in APP-knock-in mouse model of Alzheimer's disease.Semantic proximity Read ↗

Single App knock-in mouse models of Alzheimer's disease.Semantic proximity Read ↗

An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairmentsSemantic proximity Read ↗

Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease.Semantic proximity Read ↗

Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation.Semantic proximity Read ↗

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouseSemantic proximity Read ↗

APP <sup>NL-F</sup> knock-in Alzheimer’s Disease model mice reveal etiological convergence of aging and amyloidosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.