Article
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies.
Cell - 1 May 2009
Li Chengjian, Vagin Vasily V, Lee Soohyun, Xu Jia, Ma Shengmei, Xi Hualin, Seitz Hervé, Horwich Michael D, Syrzycka Monika, Honda Barry M, Kittler Ellen L W, Zapp Maria L, Klattenhoff Carla, Schulz Nadine, Theurkauf William E, Weng Zhiping, Zamore Phillip D
Abstract excerpt
Piwi-interacting RNAs (piRNAs) silence transposons in animal germ cells. piRNAs are thought to derive from long transcripts spanning transposon-rich genomic loci and to direct an autoamplification loop in which an antisense piRNA, bound to Aubergine or Piwi protein, triggers production of a sense piRNA bound to the PIWI protein Argonaute3 (Ago3). In turn, the new piRNA is envisioned to produce a second antisense...
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