Article

Mechanistic divergence of piRNA biogenesis in Drosophila

2022-11-15

Abstract excerpt

Organisms require mechanisms to distinguish self and non-self RNA. This distinction is crucial to initiate the biogenesis of piRNAs. In Drosophila ovaries, PIWI-guided slicing and the recognition of piRNA precursor transcripts by the DEAD-box RNA helicase Yb are the two known mechanisms to licence an RNA for piRNA biogenesis in the germline and the soma, respectively. Both, the PIWI proteins and Yb are highly cons...

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Literature Corpus work: c5a8e939-5114-5015-a1f6-da198e3d7acc
DOI: 10.1101/2022.11.14.516378

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