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Article

Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains.

Molecular cell - 18 Nov 2011

Zhang Zhao, Xu Jia, Koppetsch Birgit S, Wang Jie, Tipping Cindy, Ma Shengmei, Weng Zhiping, Theurkauf William E, Zamore Phillip D

Abstract excerpt

piRNAs guide PIWI proteins to silence transposons in animal germ cells. Reciprocal cycles of piRNA-directed RNA cleavage--catalyzed by the PIWI proteins Aubergine (Aub) and Argonaute3 (Ago3) in Drosophila melanogaster--expand the population of antisense piRNAs in response to transposon expression, a process called the Ping-Pong cycle. Heterotypic Ping-Pong between Aub and Ago3 ensures that antisense piRNAs...

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Identifiers

PMID: 22099305
DOI: 10.1016/j.molcel.2011.10.011
PMCID: PMC3236501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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