Article
Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms.
Molecular cell - 3 Sept 2015
Wang Wei, Han Bo W, Tipping Cindy, Ge Daniel Tianfang, Zhang Zhao, Weng Zhiping, Zamore Phillip D
Abstract excerpt
In Drosophila ovarian germ cells, PIWI-interacting RNAs (piRNAs) direct Aubergine and Argonaute3 to cleave transposon transcripts and instruct Piwi to repress transposon transcription, thereby safeguarding the germline genome. Here, we report that RNA cleavage by Argonaute3 initiates production of most Piwi-bound piRNAs. We find that the cardinal function of Argonaute3, whose piRNA guides predominantly correspond...
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