Article
Epidermal growth factor genetic variation, breast cancer risk, and waiting time to onset of disease.
DNA and cell biology - 1 May 2009
Araújo Ana Paula, Ribeiro Ricardo, Pinto Daniela, Pereira Deolinda, Sousa Berta, Mauricio Joaquina, Lopes Carlos, Medeiros Rui
Abstract excerpt
Growth factors are important mediators of proliferation. Deregulation in growth factor mechanisms as well as in its receptors will contribute to cancer development. One of the most important is the epidermal growth factor (EGF), which is encoded by EGF gene. A functional polymorphism at position 61 (A/G) is associated with increased expression of EGF. Thus, we proposed to assess genotype frequencies in a...
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