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Article

EGF genetic polymorphism is associated with clinical features but not malignant phenotype in neurofibromatosis type 1 patients.

Journal of neuro-oncology - 1 Feb 2007

Ribeiro Ricardo, Soares Angelo, Pinto Daniela, Catarino Raquel, Lopes Carlos, Medeiros Rui

Abstract excerpt

Neurofibromatosis type 1 (NF1) is characterized by a wide variation in clinical presentation and in some cases progression to malignant tumor. Epidermal growth factor (EGF) is an important mitogen for Schwann cells and is involved in the development of malignant tumors in NF1 patients. We hypothesized that EGF +61 G/A functional polymorphism, which represents constitutional all-life exposure to higher EGF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17031562
DOI: 10.1007/s11060-006-9224-z

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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