Article
Ovarian cancer and genetic susceptibility: association of A61G polymorphism in the EGF gene.
Experimental biology and medicine (Maywood, N.J.) - 1 Mar 2009
Araújo Ana Paula, Ribeiro Ricardo, Pereira Deolinda, Pinto Daniela, Sousa Berta, Catarino Raquel, Medeiros Rui
Abstract excerpt
Growth factors play an essential role in regulating cellular proliferation, and lack of control is characteristic of malignant development. The epidermal growth factor (EGF) gene codifies a growth factor that binds to the EGF receptor (EGFR), which is involved in activating pathways that promote cellular proliferation, survival, migration and differentiation. The purpose of this study was to appraise the...
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