Article
A single nucleotide polymorphism in the 5' untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2005
Hamai Yoichi, Matsumura Shunji, Matsusaki Keisuke, Kitadai Yasuhiko, Yoshida Kazuhiro, Yamaguchi Yoshiyuki, Imai Kazue, Nakachi Kei, Toge Tetsuya, Yasui Wataru
Abstract excerpt
OBJECTIVE: Epidermal growth factor (EGF) has many biological functions and plays an important role in the progression of various tumors including gastric cancer. An A-G single nucleotide polymorphism (SNP) at position 61 in the 5'-untranslated region (UTR) of the EGF gene has recently been reported to be associated with different levels of EGF production. We examined whether this polymorphism is correlated with...
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