Article
A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2008
Lanuti Michael, Liu Geoffrey, Goodwin Jonathan M, Zhai Rihong, Fuchs Bryan C, Asomaning Kofi, Su Li, Nishioka Norman S, Tanabe Kenneth K, Christiani David C
Abstract excerpt
PURPOSE: The epidermal growth factor (EGF) pathway is important in esophageal adenocarcinoma (EAC) tumorigenesis. We hypothesized that the EGF A61G homozygous variant genotype (GG) is (a) both a risk and poor prognostic factor for EAC and (b) associated with higher EGF serum levels in individuals with gastroesophageal reflux disease (GERD). EXPERIMENTAL DESIGN: Using unconditional logistic regression, we compared...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Barrett Esophagus
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Epidermal Growth Factor
- Esophageal Neoplasms