Article
Epidermal growth factor genetic variation associated with advanced cervical cancer in younger women.
American journal of clinical oncology - 1 Jun 2012
Araújo Ana Paula, Catarino Raquel, Ribeiro Ricardo, Pereira Deolinda, Pinto Daniela, Medeiros Rui
Abstract excerpt
OBJECTIVES: Epidermal growth factor (EGF) stimulates cell proliferation by binding to its receptor (epidermal growth factor receptor), and the overexpression of this receptor is associated with poorer prognosis. The EGF gene presents a polymorphism at position 61 (A/G), associated with higher EGF production. We examined the association between this polymorphism and cervical cancer through a case-control study....
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