Article
Perturbing dynamin reveals potent effects on the Drosophila circadian clock.
PloS one - 1 Jan 2009
Kilman Valerie L, Zhang Luoying, Meissner Rose-Anne, Burg Elyssa, Allada Ravi
Abstract excerpt
BACKGROUND: Transcriptional feedback loops are central to circadian clock function. However, the role of neural activity and membrane events in molecular rhythms in the fruit fly Drosophila is unclear. To address this question, we expressed a temperature-sensitive, dominant negative allele of the fly homolog of dynamin called shibire(ts1) (shi(ts1)), an active component in membrane vesicle scission. PRINCIPAL...
Topics
- Animals
- Behavior, Animal
- Biological Clocks
- Circadian Rhythm
- Drosophila
- Drosophila Proteins
- Dynamins
- Endocytosis
- Genotype