Dynamin, encoded by shibire, is central to cardiac function.

doi:10.1002/1097-010x(20010201)289:2<81::aid-jez1>3.0.co;2-t

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Article

Dynamin, encoded by shibire, is central to cardiac function.

The Journal of experimental zoology - 1 Feb 2001

Johnson E, Ringo J, Dowse H

Abstract excerpt

Employing the Drosophila heart, a model system for genetic and molecular investigation of cardiac physiology, we demonstrate here an essential role for the protein dynamin, encoded by the Drosophila gene shibire(ts) (shi(ts)), in maintaining normal heart function. In flies bearing two temperature-sensitive alleles of shi, shi(ts1) and shi(ts2), heartbeat is both slower and less rhythmic than in wild-type animals....

Topics

Animals
Drosophila
Drosophila Proteins
Dynamins
Electrocardiography
GTP Phosphohydrolases
Gene Expression Regulation
Genes, Insect
Heart
Heart Rate
Mutation
Norepinephrine
Serotonin

Source

Open in PubMed

Identifiers

PMID: 11169495
DOI: 10.1002/1097-010x(20010201)289:2<81::aid-jez1>3.0.co;2-t

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