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Article

Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.

Genetics - 1 Nov 2015

Kroll Jason R, Wong Karen G, Siddiqui Faria M, Tanouye Mark A

Abstract excerpt

One challenge in modern medicine is to control epilepsies that do not respond to currently available medications. Since seizures consist of coordinated and high-frequency neural activity, our goal was to disrupt neurotransmission with a synaptic transmission mutant and evaluate its ability to suppress seizures. We found that the mutant shibire, encoding dynamin, suppresses seizure-like activity in multiple...

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Identifiers

PMID: 26341658
DOI: 10.1534/genetics.115.177600
PMCID: PMC4649637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.PMID 26341658Read ↗

Genetic studies on dynamin function in Drosophila.Semantic proximity Read ↗

Unique biochemical and behavioral alterations in Drosophila shibire(ts1) mutants imply a conformational state affecting dynamin subcellular distribution and synaptic vesicle cycling.Semantic proximity Read ↗

Perturbing dynamin reveals potent effects on the Drosophila circadian clock.Semantic proximity Read ↗

Overexpressing temperature-sensitive dynamin decelerates phototransduction and bundles microtubules in Drosophila photoreceptors.Semantic proximity Read ↗

Targeted expression of shibire ts and semaphorin 1a reveals critical periods for synapse formation in the giant fiber of Drosophila.Semantic proximity Read ↗

A role for dynamin in triggering ethanol tolerance.Semantic proximity Read ↗

Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic.Semantic proximity Read ↗

Genetic suppression of seizure susceptibility in Drosophila.Semantic proximity Read ↗

Mutations in dynamin-related protein result in gross changes in mitochondrial morphology and affect synaptic vesicle recycling at the Drosophila neuromuscular junction.Semantic proximity Read ↗

Functional analysis of dynamin isoforms in Drosophila melanogaster.Semantic proximity Read ↗

Dynamin, encoded by shibire, is central to cardiac function.Semantic proximity Read ↗

A temperature-sensitive allele of Drosophila sesB reveals acute functions for the mitochondrial adenine nucleotide translocase in synaptic transmission and dynamin regulation.Semantic proximity Read ↗

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