Article
The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 2001
Bao S, Rihel J, Bjes E, Fan J Y, Price J L
Abstract excerpt
The Drosophila double-time (dbt) gene, which encodes a protein similar to vertebrate epsilon and delta isoforms of casein kinase I, is essential for circadian rhythmicity because it regulates the phosphorylation and stability of period (per) protein. Here, the circadian phenotype of a short-perio...
Topics
- Alleles
- Animals
- Behavior, Animal
- Casein Kinase 1 epsilon
- Cell Nucleus
- Circadian Rhythm
- Darkness
- Drosophila Proteins
- Drosophila melanogaster
- Feedback
- Gene Expression Regulation
- Immunohistochemistry
- Light
- Motor Activity
- Mutation
- Nuclear Proteins
- Period Circadian Proteins
- Periodicity