Article
Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic.
Nature - 30 May 1991
van der Bliek A M, Meyerowitz E M
Abstract excerpt
Temperature-sensitive paralysis is the most striking defect of adult Drosophila carrying the shibire mutation. This is believed to be due to a reversible block of endocytosis, which prevents membrane cycling and thus depletes synaptic vesicles. The shibire mutation also affects many tissues outsi...
Topics
- Amino Acid Sequence
- Animals
- Ca(2+) Mg(2+)-ATPase
- Cell Membrane
- Cloning, Molecular
- Drosophila Proteins
- Drosophila melanogaster
- Dynamins
- Endocytosis
- Genes
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Restriction Mapping