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Article

Dynamin Regulates Autophagy by Modulating Lysosomal Function.

Journal of genetics and genomics = Yi chuan xue bao - 20 Feb 2016

Fang Xuefei, Zhou Jia, Liu Wei, Duan Xiuying, Gala Upasana, Sandoval Hector, Jaiswal Manish, Tong Chao

Abstract excerpt

Autophagy is a central lysosomal degradation pathway required for maintaining cellular homeostasis and its dysfunction is associated with numerous human diseases. To identify players in autophagy, we tested ∼1200 chemically induced mutations on the X chromosome in Drosophila fat body clones and discovered that shibire (shi) plays an essential role in starvation-induced autophagy. shi encodes a dynamin protein...

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PMID: 26924690
DOI: 10.1016/j.jgg.2015.10.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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