Article
Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling.
Neuron - 1 Apr 2001
Krishnan K S, Rikhy R, Rao S, Shivalkar M, Mosko M, Narayanan R, Etter P, Estes P S, Ramaswami M
Abstract excerpt
Nucleoside diphosphate kinase (NDK), an enzyme encoded by the Drosophila abnormal wing discs (awd) or human nm23 tumor suppressor genes, generates nucleoside triphosphates from respective diphosphates. We demonstrate that NDK regulates synaptic vesicle internalization at the stage where function of the dynamin GTPase is required. awd mutations lower the temperature at which behavioral paralysis, synaptic failure,...
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