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Article

Blocking endocytosis in Drosophila's circadian pacemaker neurons interferes with the endogenous clock in a PDF-dependent way.

Chronobiology international - 1 Oct 2009

Wülbeck Corinna, Grieshaber Eva, Helfrich-Förster Charlotte

Abstract excerpt

The neuropeptide pigment-dispersing factor (PDF) plays an essential role in the circadian clock of the fruit fly Drosophila melanogaster, but many details of PDF signaling in the clock network are still unknown. We tried to interfere with PDF signaling by blocking the GTPase Shibire in PDF neurons. Shibire is an ortholog of the mammalian Dynamins and is essential for endocytosis of clathrin-coated vesicles at the...

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PMID: 19916833
DOI: 10.3109/07420520903433315

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PDF

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