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Article

p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2009

Cescon David W, Bradbury Penelope A, Asomaning Kofi, Hopkins Jessica, Zhai Rihong, Zhou Wei, Wang Zhaoxi, Kulke Matthew, Su Li, Ma Clement, Xu Wei, Marshall Ariela L, Heist Rebecca Suk, Wain John C, Lynch Thomas J, Christiani David C, Liu Geoffrey

Abstract excerpt

PURPOSE: This study aimed to evaluate the prognostic significance of two functional single nucleotide polymorphisms (SNP) in the p53 pathway (p53 Arg72Pro and MDM2 T309G) in patients with esophageal cancer, and to determine the importance of histologic subtype in the SNP-outcome relationships. EXPERIMENTAL DESIGN: A cohort of 371 patients with esophageal carcinoma enrolled in Boston, USA from 1999 to 2004 were...

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Identifiers

PMID: 19383811
DOI: 10.1158/1078-0432.CCR-08-3120
PMCID: PMC3081782

Genes

MDM2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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