Article
p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus - 1 Jan 2010
Liu G, Cescon D W, Zhai R, Zhou W, Kulke M H, Ma C, Xu W, Su L, Asomaning K, Heist R S, Wain J C, Lynch T J, Christiani D C
Abstract excerpt
p53 Arg72Pro, MDM2 T309G, and CCND1 G870A are functional single-nucleotide polymorphisms (SNPs) in key genes that regulate apoptosis and cell cycle. Variant genotypes of these SNPs have been associated with increased risk and earlier age of onset in some cancers. We investigated the association of these SNPs with susceptibility to esophageal adenocarcinoma in a large, North American case-control study. Three...
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