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Article

Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma.

Journal of gastroenterology and hepatology - 1 Sept 2013

Renouf Daniel J, Zhai Rihong, Sun Bin, Xu Wei, Cheung Winson Y, Heist Rebecca S, Kulke Matthew H, Cescon David, Asomaning Kofi, Marshall Ariella L, Li Su, Christiani David C, Liu Geoffrey

Abstract excerpt

BACKGROUND AND AIM: Although gastroesophageal reflux disease (GERD) is a risk factor for esophageal adenocarcinoma (EAC), some patients develop EAC in the absence of GERD. A putative mechanism of reflux-induced tumorigenesis involves disruptions in the p53 pathway. We assessed the interaction of GERD and p53 pathway polymorphisms on EAC prognosis. METHODS: In a prospective cohort of 358 EAC patients, clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Source

Identifiers

PMID: 23735059
DOI: 10.1111/jgh.12286

Genes

MDM2
AHR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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