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Article

MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jun 2007

Heist Rebecca Suk, Zhou Wei, Chirieac Lucian R, Cogan-Drew Thea, Liu Geoffrey, Su Li, Neuberg Donna, Lynch Thomas J, Wain John C, Christiani David C

Abstract excerpt

PURPOSE: MDM2 is a negative regulator of p53. The MDM2 309T/G polymorphism has been associated with differential MDM2 expression levels and inhibition of the p53 pathway. We hypothesized that the MDM2 G/G genotype may be associated with worse survival outcomes in lung cancer, especially in squamo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17538168
DOI: 10.1200/JCO.2006.08.8914

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17538168-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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