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Article

The role of P53 and MDM2 polymorphisms in the risk of esophageal squamous cell carcinoma.

Cancer research - 15 Oct 2005

Hong Yuan, Miao Xiaoping, Zhang Xuemei, Ding Fang, Luo Aiping, Guo Yongli, Tan Wen, Liu Zhihua, Lin Dongxin

Abstract excerpt

The tumor suppressor P53 pathway plays a crucial role in preventing carcinogenesis and genetic variations of this pathway may be associated with cancer susceptibility. We tested this hypothesis by examining the contribution of functional polymorphisms in P53 and MDM2 to risk of esophageal squamous cell carcinoma (ESCC). DNA from 758 ESCC patients and 1,420 controls were genotyped for P53 codon 72Arg>Pro and MDM2...

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Source

Identifiers

PMID: 16230424
DOI: 10.1158/0008-5472.CAN-05-1460

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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