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Article

MDM2 promoter polymorphism and pancreatic cancer risk and prognosis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2008

Asomaning Kofi, Reid Amy E, Zhou Wei, Heist Rebecca S, Zhai Rihong, Su Li, Kwak Eunice L, Blaszkowsky Lawrence, Zhu Andrew X, Ryan David P, Christiani David C, Liu Geoffrey

Abstract excerpt

PURPOSE: The mouse double minute 2 homologue (MDM2) -309T/G promoter polymorphism has been associated recently with the development and prognosis of a variety of tumors. The G allele is associated with increased affinity for Sp1 binding and higher MDM2 mRNA and protein levels, leading to diminished tumor suppressor activity of the p53 pathway. We hypothesized that the G allele is also associated with increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Source

Identifiers

PMID: 18559624
DOI: 10.1158/1078-0432.CCR-07-4187

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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