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Article

Assembled DJ beta complexes influence TCR beta chain selection and peripheral V beta repertoire.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2009

Carpenter Andrea C, Yang-Iott Katherine S, Chao Linda H, Nuskey Beth, Whitlow Scott, Alt Frederick W, Bassing Craig H

Abstract excerpt

TCRbeta chain repertoire of peripheral alphabeta T cells is generated through the stepwise assembly and subsequent selection of TCRbeta V region exons during thymocyte development. To evaluate the influence of a two-step recombination process on Vbeta rearrangement and selection, we generated mice with a preassembled Dbeta1Jbeta1.1 complex on the Jbeta1(omega) allele, an endogenous TCRbeta allele that lacks the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

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Identifiers

PMID: 19380806
DOI: 10.4049/jimmunol.0803270
PMCID: PMC5703067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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