Article
Functional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locus.
Molecular immunology - 1 Jan 2009
Khor Bernard, Mahowald Grace K, Khor Katrina, Sleckman Barry P
Abstract excerpt
The second exon of lymphocyte antigen receptor genes is assembled in developing lymphocytes from component V, J and, in some cases, D gene segments through the process of V(D)J recombination. This process is initiated by an endonuclease comprised of the Rag-1 and Rag-2 proteins, collectively referred to as Rag. Rag binds to recombination signals (RSs) and catalyzes the pair-wise introduction of DNA double strand...
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