Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombination.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Ryu Chun Jeih, Haines Brian B, Draganov Dobrin D, Kang Yun Hee, Whitehurst Charles E, Schmidt Tara, Hong Hyo Jeong, Chen Jianzhu

Abstract excerpt

The precise function of cis elements in regulating V(D)J recombination is still controversial. Here, we determined the effect of inactivation of the TCRbeta enhancer (Ebeta) on cleavage and rearrangement of Dbeta1, Dbeta2, Jbeta1, and Jbeta2 gene segments in CD4-CD8- [double-negative (DN)] and CD4+CD8+ [double-positive (DP)] thymocytes. In Ebeta-deficient mice, (i) Dbeta1 rearrangements were more severely...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Southern
Share to CD4 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD8 Antigens

Share to Enhancer Elements, Genetic

Share to Gene Rearrangement

Share to Genes, T-Cell Receptor beta

Share to Thymus Gland

Share to VDJ Recombinases

Source

Open in PubMed Open full text

Identifiers

PMID: 14593206
DOI: 10.1073/pnas.2235807100
PMCID: PMC263837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombination.PMID 14593206Read ↗

Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.Semantic proximity Read ↗

Assessing the role of the T cell receptor beta gene enhancer in regulating coding joint formation during V(D)J recombination.Semantic proximity Read ↗

Functional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locus.Semantic proximity Read ↗

Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model.Semantic proximity Read ↗

Disruption of the lineage restriction of TCR beta gene rearrangements.Semantic proximity Read ↗

Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.Semantic proximity Read ↗

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.Semantic proximity Read ↗

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.Semantic proximity Read ↗

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.Semantic proximity Read ↗

Molecular genetics at the T-cell receptor beta locus: insights into the regulation of V(D)J recombination.Semantic proximity Read ↗

Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion.Semantic proximity Read ↗

Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.