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Article

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme.

The Journal of experimental medicine - 11 May 2009

Malynn Barbara A, Ma Averil

Abstract excerpt

Many B cell cancers are characterized in part by the dysregulation of the NF-kappaB signaling pathway. A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-kappaB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas. These data reveal the role of A20 as a tumor suppressor protein.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, B-Cell

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Share to Tumor Necrosis Factor alpha-Induced Protein 3

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Source

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Identifiers

PMID: 19380636
DOI: 10.1084/jem.20090765
PMCID: PMC2715039

Genes

TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme.PMID 19380636Read ↗

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