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Article

Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

Nature - 4 Jun 2009

Compagno Mara, Lim Wei Keat, Grunn Adina, Nandula Subhadra V, Brahmachary Manisha, Shen Qiong, Bertoni Francesco, Ponzoni Maurilio, Scandurra Marta, Califano Andrea, Bhagat Govind, Chadburn Amy, Dalla-Favera Riccardo, Pasqualucci Laura

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma in adulthood, comprises multiple biologically and clinically distinct subtypes including germinal centre B-cell-like (GCB) and activated B-cell-like (ABC) DLBCL. Gene expression profile studies have shown that its most aggressive subtype, ABC-DLBCL, is associated with constitutive activation of the NF-kappaB transcription complex. However,...

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Topics

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Share to Apoptosis
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Lymphoma, Large B-Cell, Diffuse

Share to NF-kappa B

Share to Nuclear Proteins

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Open in PubMed Open full text

Identifiers

PMID: 19412164
DOI: 10.1038/nature07968
PMCID: PMC2973325

Genes

CARD11
TRAF2
TNFAIP3
TRAF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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