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Article

Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling.

Molecular cell - 24 Nov 2010

Bosanac Ivan, Wertz Ingrid E, Pan Borlan, Yu Christine, Kusam Saritha, Lam Cynthia, Phu Lilian, Phung Qui, Maurer Brigitte, Arnott David, Kirkpatrick Donald S, Dixit Vishva M, Hymowitz Sarah G

Abstract excerpt

Inactivating mutations in the ubiquitin (Ub) editing protein A20 promote persistent nuclear factor (NF)-κB signaling and are genetically linked to inflammatory diseases and hematologic cancers. A20 tightly regulates NF-κB signaling by acting as an Ub editor, removing K63-linked Ub chains and mediating addition of Ub chains that target substrates for degradation. However, a precise molecular understanding of how...

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PMID: 21095585
DOI: 10.1016/j.molcel.2010.10.009

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