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Article

Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion.

Diabetes - 1 Jul 2009

Müssig Karsten, Staiger Harald, Machicao Fausto, Kirchhoff Kerstin, Guthoff Martina, Schäfer Silke A, Kantartzis Konstantinos, Silbernagel Günther, Stefan Norbert, Holst Jens J, Gallwitz Baptist, Häring Hans-Ulrich, Fritsche Andreas

Abstract excerpt

OBJECTIVE: KCNQ1 gene polymorphisms are associated with type 2 diabetes. This linkage appears to be mediated by altered beta-cell function. In an attempt to study underlying mechanisms, we examined the effect of four KCNQ1 single nucleotide polymorphisms (SNPs) on insulin secretion upon different stimuli. RESEARCH DESIGN AND METHODS: We genotyped 1,578 nondiabetic subjects at increased risk of type 2 diabetes for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19366866
DOI: 10.2337/db08-1589
PMCID: PMC2699873

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion.PMID 19366866Read ↗

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