Article
The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load.
PloS one - 11 Jun 2009
Holmkvist Johan, Banasik Karina, Andersen Gitte, Unoki Hiroyuki, Jensen Thomas Skot, Pisinger Charlotta, Borch-Johnsen Knut, Sandbaek Annelli, Lauritzen Torsten, Brunak Sören, Maeda Shiro, Hansen Torben, Pedersen Oluf
Abstract excerpt
BACKGROUND: Polymorphisms in the potassium channel, voltage-gated, KQT-like subfamily, member 1 (KCNQ1) have recently been reported to associate with type 2 diabetes. The primary aim of the present study was to investigate the putative impact of these KCNQ1 polymorphisms (rs2283228, rs2237892, rs2237895, and rs2237897) on estimates of glucose stimulated insulin release. METHODOLOGY/PRINCIPAL FINDINGS: Genotypes...
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