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Article

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion.

Diabetologia - 1 Jun 2009

Schäfer S A, Müssig K, Staiger H, Machicao F, Stefan N, Gallwitz B, Häring H U, Fritsche A

Abstract excerpt

AIMS/HYPOTHESIS: WFS1 type 2 diabetes risk variants appear to be associated with impaired beta cell function, although it is unclear whether insulin secretion is affected directly or secondarily via alteration of insulin sensitivity. We aimed to investigate the effect of a common WFS1 single-nucleotide polymorphism on several aspects of insulin secretion. METHODS: A total of 1,578 non-diabetic individuals (534...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19330314
DOI: 10.1007/s00125-009-1344-5

Genes

WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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