Article
Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.
Diabetes - 1 Jun 2009
Tan Jonathan T, Nurbaya Siti, Gardner Daphne, Ye Sandra, Tai E Shyong, Ng Daniel P K
Abstract excerpt
OBJECTIVE: The potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) has been found through a genome-wide association study to be a strong candidate for conferring susceptibility to type 2 diabetes in East Asian and European populations. Our objective was to describe the association between polymorphisms at the KCNQ1 locus with insulin resistance, beta-cell function, and other type 2...
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