Article
Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp.
PloS one - 1 Jan 2012
van Vliet-Ostaptchouk Jana V, van Haeften Timon W, Landman Gijs W D, Reiling Erwin, Kleefstra Nanne, Bilo Henk J G, Klungel Olaf H, de Boer Anthonius, van Diemen Cleo C, Wijmenga Cisca, Boezen H Marike, Dekker Jacqueline M, van 't Riet Esther, Nijpels Giel, Welschen Laura M C, Zavrelova Hata, Bruin Elinda J, Elbers Clara C, Bauer Florianne, Onland-Moret N Charlotte, van der Schouw Yvonne T, Grobbee Diederick E, Spijkerman Annemieke M W, van der A Daphne L, Simonis-Bik Annemarie M, Eekhoff Elisabeth M W, Diamant Michaela, Kramer Mark H H, Boomsma Dorret I, de Geus Eco J, Willemsen Gonneke, Slagboom P Eline, Hofker Marten H, 't Hart Leen M
Abstract excerpt
BACKGROUND: Genome-wide association studies in Japanese populations recently identified common variants in the KCNQ1 gene to be associated with type 2 diabetes. We examined the association of these variants within KCNQ1 with type 2 diabetes in a Dutch population, investigated their effects on insulin secretion and metabolic traits and on the risk of developing complications in type 2 diabetes patients....
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