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Article

Effect of a common variant of the PCSK2 gene on reduced insulin secretion.

Diabetologia - 1 Dec 2012

Jonsson A, Isomaa B, Tuomi T, Eriksson J G, Groop L, Lyssenko V

Abstract excerpt

AIM/HYPOTHESIS: Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. The aims of the present study were to replicate the association between genetic variants of the PCSK2 gene and...

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Source

Identifiers

PMID: 23011353
DOI: 10.1007/s00125-012-2728-5

Genes

PCSK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Effect of a common variant of the PCSK2 gene on reduced insulin secretion.PMID 23011353Read ↗

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