Article
Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells.
American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2009
Balakathiresan Nagaraja Sethuraman, Bhattacharyya Sharmistha, Gutti Usha, Long Robert P, Jozwik Catherine, Huang Wei, Srivastava Meera, Pollard Harvey B, Biswas Roopa
Abstract excerpt
Cystic fibrosis (CF) is due to mutations in the CFTR gene and is characterized by hypersecretion of the proinflammatory chemokine IL-8 into the airway lumen. Consequently, this induces the highly inflammatory cellular phenotype typical of CF. Our initial studies revealed that IL-8 mRNA is relatively stable in CF cells compared with those that had been repaired with [WT]CFTR (wild-type CFTR). Relevantly, the...
Topics
- Adenine
- Cell Line
- Cystic Fibrosis
- Epithelial Cells
- Gene Expression Regulation
- Humans
- Interleukin-8
- Phenotype
- RNA Stability
- RNA, Messenger
- Respiratory Mucosa
- Tristetraprolin