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Article

Somatic mRNA turnover mutants implicate tristetraprolin in the interleukin-3 mRNA degradation pathway.

Molecular and cellular biology - 1 Jun 2000

Stoecklin G, Ming X F, Looser R, Moroni C

Abstract excerpt

Control of mRNA stability is critical for expression of short-lived transcripts from cytokines and proto-oncogenes. Regulation involves an AU-rich element (ARE) in the 3' untranslated region (3'UTR) and cognate trans-acting factors thought to promote either degradation or stabilization of the mRNA. In this study we present a novel approach using somatic cell genetics designed to identify regulators of...

Topics

Animals
DNA-Binding Proteins
Genes, Reporter
Genetic Complementation Test
Humans
Immediate-Early Proteins
Interleukin-3
Mice
Mutagenesis
Phenotype
Proteins
RNA Stability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Tristetraprolin

Tumor Cells, Cultured

Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 10805719
DOI: 10.1128/MCB.20.11.3753-3763.2000
PMCID: PMC85689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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