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Article

Tristetraprolin regulates interleukin-6 expression through p38 MAPK-dependent affinity changes with mRNA 3' untranslated region.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Aug 2011

Zhao Wenpu, Liu Min, D'Silva Nisha J, Kirkwood Keith L

Abstract excerpt

Tristetraprolin (TTP) is a well-characterized, zinc finger-containing, RNA-binding protein. TTP targets tumor necrosis factor α for degradation via the 3' untranslated region (3'UTR). Although AU-rich elements (AREs) in the 3'UTR of interleukin-6 (IL-6) mRNA dictate mRNA degradation, the role of TTP in the post-transcriptional regulation of IL-6 gene expression is unclear. Here we used TTP-deficient mice to test...

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Identifiers

PMID: 21457063
DOI: 10.1089/jir.2010.0154
PMCID: PMC3151618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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