Article
MAPK signaling pathways regulate IL-8 mRNA stability and IL-8 protein expression in cystic fibrosis lung epithelial cell lines.
American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2011
Bhattacharyya Sharmistha, Gutti Usha, Mercado Jose, Moore Chad, Pollard Harvey B, Biswas Roopa
Abstract excerpt
Cystic fibrosis (CF) is characterized by a massive proinflammatory phenotype in the lung, caused by mutations in the CFTR gene. IL-8 and other proinflammatory mediators are elevated in the CF airway, and the immediate mechanism may depend on disease-specific stabilization of IL-8 mRNA in CF lung epithelial cells. MAPK signaling pathways impact directly on IL-8 protein expression in CF cells, and we have...
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