Article
Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo.
Molecular and cellular biology - 1 Jun 2017
O'Neil John D, Ross Ewan A, Ridley Michael L, Ding Qize, Tang Tina, Rosner Dalya R, Crowley Thomas, Malhi Deepak, Dean Jonathan L, Smallie Tim, Buckley Christopher D, Clark Andrew R
Abstract excerpt
The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manner to the 3' untranslated regions of many proinflammatory mRNAs and recruits complexes of nucleases to promote rapid mRNA turnover. Mice lacking TTP develop a severe, spontaneous inflammatory syndrome characterized by the overexpression of tumor necrosis factor and other inflammatory mediators. However, TTP also employs the same...
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