Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-17 Regulates CXCL1 mRNA Stability via an AUUUA/Tristetraprolin-Independent Sequence

30 Dec 2009

Abstract excerpt

IL-17 contributes to inflammatory response in part by promoting enhanced expression of chemokines, such as CXCL1, by prolonging the t(1/2) of this constitutively unstable mRNA. Although IL-17 is a weak stimulus for transcription of the CXCL1 gene, it strongly potentiates message accumulation via stabilization when the mRNA is transcribed in cells stimulated with TNF. In myeloid cells, LPS-induced CXCL1 mRNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Cytokine Signaling Pathways and Interactions
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20042592
DOI: 10.4049/jimmunol.0902423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-17 Regulates CXCL1 mRNA Stability via an AUUUA/Tristetraprolin-Independent SequencePMID 20042592Read ↗

Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo.Semantic proximity Read ↗

Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells.Semantic proximity Read ↗

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.Semantic proximity Read ↗

Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stabilitySemantic proximity Read ↗

Functional Analysis of KSRP Interaction with the AU-Rich Element of Interleukin-8 and Identification of Inflammatory mRNA TargetsSemantic proximity Read ↗

Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.Semantic proximity Read ↗

Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in MiceSemantic proximity Read ↗

Sustained stabilization of Interleukin-8 mRNA in human macrophagesSemantic proximity Read ↗

Heterogeneity in Control of mRNA Stability by AU-rich ElementsSemantic proximity Read ↗

Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in MiceSemantic proximity Read ↗

Somatic mRNA turnover mutants implicate tristetraprolin in the interleukin-3 mRNA degradation pathway.Semantic proximity Read ↗

The p38 MAPK Regulates IL-24 Expression by Stabilization of the 3′ UTR of IL-24 mRNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.