Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in Mice

Abstract excerpt

Th17 cells have been extensively investigated in inflammation, autoimmune diseases and cancer. The precise molecular mechanisms for Th17 cell regulation, however, remain elusive, especially regulation at the posttranscriptional level. Tristetraprolin (TTP) is an RNA-binding protein important for degradation of the mRNAs encoding several proinflammatory cytokines. With newly generated T cell-specific TTP...