Article
Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice
2 Sept 2020
Abstract excerpt
Tristetraprolin (TTP) is a mRNA binding protein that binds to adenylate-uridylate-rich elements within the 3’ untranslated regions of certain transcripts, such as tumor necrosis factor (Tnf), and increases their rate of decay. Modulation of TTP expression is implicated in inflammation; however, its role in acute lung inflammation remains unknown. Accordingly, we tested the role of TTP in lipopolysaccharide...