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Article

Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.

Molecular cell - 10 Apr 2009

Matyskiela Mary E, Morgan David O

Abstract excerpt

The anaphase-promoting complex or cyclosome (APC/C) is a ubiquitin ligase essential for the completion of mitosis in all eukaryotic cells. Substrates are recruited to the APC/C by activator proteins (Cdc20 or Cdh1), but it is not known where substrates are bound during catalysis. We explored this problem by analyzing mutations in the tetratricopeptide-repeat-containing APC/C subunits. We identified residues in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19362536
DOI: 10.1016/j.molcel.2009.02.027
PMCID: PMC2754851

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.PMID 19362536Read ↗

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