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Article

Mitotic regulation of the APC activator proteins CDC20 and CDH1.

Molecular biology of the cell - 1 May 2000

Kramer E R, Scheuringer N, Podtelejnikov A V, Mann M, Peters J M

Abstract excerpt

The ordered activation of the ubiquitin protein ligase anaphase-promoting complex (APC) or cyclosome by CDC20 in metaphase and by CDH1 in telophase is essential for anaphase and for exit from mitosis, respectively. Here, we show that CDC20 can only bind to and activate the mitotically phosphorylated form of the Xenopus and the human APC in vitro. In contrast, the analysis of phosphorylated and nonphosphorylated...

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Share to Anaphase-Promoting Complex-Cyclosome
Share to Cdc20 Proteins
Share to Cyclin B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 10793135
DOI: 10.1091/mbc.11.5.1555
PMCID: PMC14867

Genes

APC
CDH1
CDC20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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