Article
Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box.
Molecular cell - 27 May 2005
Burton Janet L, Tsakraklides Vasiliki, Solomon Mark J
Abstract excerpt
The anaphase-promoting complex (APC) is a ubiquitin ligase that promotes the degradation of cell-cycle regulators. Cdh1p is an APC coactivator that directly binds APC substrates. A genetic screen in budding yeast identified residues within Cdh1p critical for its function. Cdh1p proteins containing mutations within the "C box" or the "IR" motif could bind substrate, but not the APC, whereas mutants that only bound...
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