Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

How APC/C-Cdc20 changes its substrate specificity in mitosis.

Nature cell biology - 1 Mar 2011

Izawa Daisuke, Pines Jonathon

Abstract excerpt

Progress through mitosis requires that the right protein be degraded at the right time. One ubiquitin ligase, the anaphase-promoting complex or cyclosome (APC/C) targets most of the crucial mitotic regulators by changing its substrate specificity throughout mitosis. The spindle assembly checkpoint (SAC) acts on the APC/C co-activator, Cdc20 (cell division cycle 20), to block the degradation of metaphase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase-Promoting Complex-Cyclosome
Share to Cdc20 Proteins
Share to Cyclin A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin B1

Share to Metaphase

Share to Securin

Share to Spindle Apparatus

Share to Ubiquitin-Protein Ligase Complexes

Source

Open in PubMed Open full text

Identifiers

PMID: 21336306
DOI: 10.1038/ncb2165
PMCID: PMC3059483

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How APC/C-Cdc20 changes its substrate specificity in mitosis.PMID 21336306Read ↗

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Semantic proximity Read ↗

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.Semantic proximity Read ↗

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast.Semantic proximity Read ↗

Cyclin-dependent kinase 1-dependent activation of APC/C ubiquitin ligase.Semantic proximity Read ↗

SUMO targets the APC/C to regulate transition from metaphase to anaphaseSemantic proximity Read ↗

Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.Semantic proximity Read ↗

Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.Semantic proximity Read ↗

Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)Semantic proximity Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.